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. 2022 Aug 3;27(15):4934. doi: 10.3390/molecules27154934

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© 2022 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Model for the Moco biosynthesis pathway in plants, published by Schwarz et al. in the year 2000 [129]. Cnx1 is shown to be bound to an actin filament. An unidentified molybdate transport system was proposed that interacts with Cnx1 to facilitate molybdate channeling to the E domain, given that a mutation in this protein results in a molybdate-repairable phenotype. The conversion of precursorZ cPMP) to MPT by the MPT synthase (Cnx6 and Cnx7) is shown. MPT is highly sensitive to oxidation; therefore, it was suggested that the rapid conversion of precursorZ to Moco should occur in a multienzyme complex anchored by Cnx1 on the cytoskeleton. Modified after Schwarz et al. [129].