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. 2022 Jul 28;13:933312. doi: 10.3389/fimmu.2022.933312

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Copyright © 2022 Li, Li, Liu, Zhu, Zhou, Xiao, Hou, Lin, Chen and Peng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Classification of CU lipid subtypes based on profiling. (A) The heat map corresponding to the consensus matrix for 2 metabolite subtypes was obtained by applying consensus clustering. (B) CU was classified into two subtypes based on lipid profiling, subtype 2 shared higher UCT scores compared with subtype 1. (C) The heatmap of all differential lipids related with subtype 1 (blue) and subtype 2 (orange), which was generated using the heatmap function in R with subtypes, UAS7 (green), DLQI (purple) score and UCT (blue) score as the annotations. The colors range from blue to red, indicating strength from low to high. (D, E) Plasma PC (18:0e/18:2) (R=-0.28, P-value=0.041) and PE (38:2) (R=-0.29, P-value=0.038) levels were negatively correlated with UCT scores.