Table 6.
Compounds | MAO-A IC50 | MAO-B IC50 | SI |
---|---|---|---|
(1) | 26.3 ± 1.03 μM | 153.25 ± 1.58 nM | 172 |
selegiline | 67.24 ± 1.03 μM | 19.58 ± 0.83 nM | 3434 |
iproniazide | 6.55 ± 0.75 μM | 7.52 ± 0.34 μM | 0.87 |
Each IC50 value is the mean ± S.E.M. from three experiments. SI: MAO-B selectivity index = IC50 (MAO-A)/IC50 (MAO-B).