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Synthesis of Cyclopropyl Bisphosphate Derivative, Compound 19a
a Reaction conditions: (i) 2-chloro-N6-methylaminopurine, K2CO3, DMF, 35 °C, 2 d, 41%; (ii) DIBAL, CH2Cl2, −78 °C to rt, 2 h, 70%; (iii) Et2NP(OtBu)2, tetrazole, THF, rt, 20 min then MCPBA, 85%; (iv) 5% TFA in CH2Cl2, rt, 20 min, 61%.
