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. Author manuscript; available in PMC: 2022 Aug 11.
Published in final edited form as: J Med Chem. 2001 Sep 13;44(19):3092–3108. doi: 10.1021/jm010082h

Scheme 1.

Scheme 1.

Synthesis of Isopropyl Bisphosphate, Compound 5a

a Reaction conditions: (i) NaBH4, EtOH, 0 °C, 30 min, 91%; (ii) 2,6-dichloropurine, DEAD, PPh3, THF, rt, overnight, 68%; (iii) CH3NH2, THF, rt, 4 h, 88%; (iv) Dowex 50x-8 200, MeOH, reflux, overnight, 75%; (v) Et2NP(OtBu)2, tetrazole, THF, rt, 20 min, then MCPBA, 73%; (vi) Dowex 50x-8 200, MeOH:H2O = 1:1, 80 °C, 16 h, 63%.