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. 2022 Aug 1;14(15):3138. doi: 10.3390/polym14153138

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Photomicrograph showing Hematoxylin and Eosin stained (H&E) (×40) sections of kidney with asterisk showing kidney tubules and arrow showing glomerulus. (A) Control group with regular shape of glomerulus and distinguishable collecting duct and renal tubule. (B) Untreated diabetic group showing irregular renal cells distribution, tubules dilation, and glomerulosclerosis. (C) The diabetic metformin-treated group shows somewhat normal appearance of tubules and intact glomerular boundary when compared to the diabetic group. (D) Diabetic-AgNPs treated (5 mg/kg) group showing restoration of glomerular boundary and intact kidney tubules. (E) Diabetic AgNP (10 mg/kg) treated group show more reno-protective activity as compared to the standard metformin with complete restoration of glomerulus and renal tubules.