The degradation of PHBV freeze-dried scaffolds. (A) Percentage of weight loss along the immersion time in PBS, lipase, lysozyme, and lipase/lysozyme, at pH 7.4 and 37.8 °C. The macroscopic images represent the appearance of the freeze-dried scaffolds under the different conditions at specific time points. (B) The SEM images of the PHBV scaffolds before (day 0) and after 4 and 8 weeks of immersion in PBS, lipase, lysozyme, and lipase/Lysozyme. Images in the upper right corners represent magnified areas highlighting the topography of the pore wall surfaces. Samples immersed in lipase/lysozyme solution for 8 weeks were completely degraded and therefore no image corresponding to that condition is shown. Reproduced from [146], with permission from John Wiley and Sons, 2022.