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. 2022 Aug 1;18(8):e1010737. doi: 10.1371/journal.ppat.1010737

Table 1. A list of the 25 most negatively regulated genes in Ea1189Δ12 relative to WT Ea1189.

Locus Tag Gene ID Product Differential Expression Log2 Ratio Differential Expression p-value
EAM_RS16610 insulinase family protein CDS insulinase family protein -11.66137022 1.9342E-136
EAM_RS16615 dicarboxylate/amino acid:cation symporter CDS dicarboxylate/amino acid:cation symporter -10.81381354 5.2721E-119
EAM_RS19445 hypothetical protein CDS hypothetical protein -7.950021219 9.05238E-26
EAM_RS11745 DUF1471 domain-containing protein CDS DUF1471 domain-containing protein -5.590416774 3.0468E-177
EAM_RS16620 hmsP CDS biofilm formation regulator HmsP -5.50909201 4.6447E-238
EAM_RS05505 amino acid ABC transporter substrate-binding protein CDS amino acid ABC transporter substrate-binding protein -5.30482975 0
EAM_RS05285 leucine-rich repeat domain-containing protein CDS leucine-rich repeat domain-containing protein -4.983851837 0
EAM_RS12130 APC family permease CDS APC family permease -4.936317974 1.0207E-268
EAM_RS00070 rbsD CDS D-ribose pyranase -4.850327937 0
EAM_RS09500 htpX CDS protease HtpX -4.366262025 1.1091E-160
EAM_RS10695 mglB CDS galactose/glucose ABC transporter substrate-binding protein MglB -4.247135295 0
EAM_RS09990 hypothetical protein CDS hypothetical protein -4.127207088 0
EAM_RS06765 yccA CDS FtsH protease modulator YccA -4.094370008 0
EAM_RS02625 glucitol/sorbitol permease IIC component CDS glucitol/sorbitol permease IIC component -4.082619297 0
EAM_RS01695 acs CDS acetate—CoA ligase -3.99767443 4.442E-206
EAM_RS02150 groL CDS chaperonin GroEL -3.934347101 3.1088E-288
EAM_RS12125 dihydrodipicolinate synthase family protein CDS dihydrodipicolinate synthase family protein -3.872046115 9.868E-140
EAM_RS07820 spy CDS ATP-independent periplasmic protein-refolding chaperone Spy -3.854421997 2.9565E-168
EAM_RS15970 pckA CDS phosphoenolpyruvate carboxykinase (ATP) -3.798261114 0
EAM_RS09315 gapA CDS glyceraldehyde-3-phosphate dehydrogenase -3.766942859 1.4129E-220
EAM_RS12115 4-hydroxyproline epimerase CDS 4-hydroxyproline epimerase -3.671073648 1.6735E-263
EAM_RS12095 aldehyde dehydrogenase (NADP(+)) CDS aldehyde dehydrogenase (NADP(+)) -3.568133834 2.0155E-186
EAM_RS08865 pspB CDS envelope stress response membrane protein PspB -3.567808565 2.2995E-247
EAM_RS14660 ribB CDS 3,4-dihydroxy-2-butanone-4-phosphate synthase -3.507981226 2.2124E-252
EAM_RS00630 hslU CDS HslU—HslV peptidase ATPase subunit -3.473822217 1.301E-247