Table 1.
Predicted KEGG functional pathway differences at level 2 inferred from 16S rRNA gene sequences using PICRUSt during T. spiralis infection with or without LNT.
| Functional categories | ||||||
|---|---|---|---|---|---|---|
| Level 1 | Level 2 | Con:mean ± sd(%) | Ts:mean ± sd(%) | TsLNT:mean ± sd(%) | Con vs Ts p value | TsLNT vs Ts p value |
| Cellular Processes | Cell motility | 1.227± 0.251 |
0.173± 0.098 |
1.012± 0.271 |
<0.001 | <0.001 |
| Cellular community - prokaryotes | 1.468± 0.079 |
1.183± 0.115 |
1.472± 0.032 |
0.001 | 0.002 | |
| Transport and catabolism | 0.278± 0.07 |
0.138± 0.025 |
0.303± 0.038 |
0.005 | <0.001 | |
| Environmental Information Processing | Signal transduction | 2.772± 0.171 |
2.181± 0.127 |
2.691± 0.137 |
<0.001 | <0.001 |
| Genetic Information Processing | Folding, sorting and degradation | 1.586± 0.03 |
1.727± 0.06 |
1.573± 0.022 |
0.002 | 0.001 |
| Human Diseases | Cancers: Overview | 0.507± 0.025 |
0.686± 0.035 |
0.501± 0.01 |
<0.001 | <0.001 |
| Drug resistance: Antimicrobial | 1.01± 0.025 |
0.862± 0.039 |
1.023± 0.03 |
<0.001 | <0.001 | |
| Infectious diseases: Parasitic | 0.022± 0.005 |
0.046± 0.007 |
0.037± 0.002 |
<0.001 | 0.007 | |
| Cancers: Specific types | 0.046± 0.007 |
0.177± 0.046 |
0.045± 0.003 |
0.001 | 0.001 | |
| Neurodegenerative diseases | 0.132± 0.032 |
0.354± 0.166 |
0.114± 0.01 |
0.001 | 0.002 | |
| Infectious diseases: Viral | 0.006± 0.006 |
0.044± 0.029 |
0.005± 0.002 |
0.027 | 0.034 | |
| Metabolism | Metabolism of other amino acids | 1.333± 0.056 |
1.781± 0.052 |
1.37± 0.081 |
0.029 | 0.029 |
| Metabolism of terpenoids and polyketides | 1.07± 0.013 |
1.183± 0.017 |
1.054± 0.015 |
0.030 | 0.023 | |
| Xenobiotics biodegradation and metabolism | 0.757± 0.081 |
1.34± 0.144 |
0.821± 0.088 |
0.032 | 0.031 | |
| Energy metabolism | 3.852± 0.181 |
4.569± 0.189 |
3.839± 0.023 |
0.000 | 0.000 | |
| Biosynthesis of other secondary metabolites | 1.038± 0.06 |
0.727± 0.104 |
1.062± 0.015 |
<0.001 | <0.001 | |
| Glycan biosynthesis and metabolism | 1.558± 0.193 |
1.169± 0.024 |
1.611± 0.093 |
<0.001 | <0.001 | |
| Carbohydrate metabolism | 10.04± 0.266 |
9.078± 0.541 |
10.15± 0.177 |
<0.001 | <0.001 | |
| Organismal Systems | Nervous system | 0.207± 0.009 |
0.124± 0.025 |
0.215± 0.008 |
<0.001 | 0.001 |
| Aging | 0.282± 0.016 |
0.407± 0.057 |
0.272± 0.001 |
0.006 | <0.001 | |
| Immune system | 0.077± 0.005 |
0.044± 0.017 |
0.079± 0.003 |
0.009 | 0.005 | |
| Circulatory system | 0.004± 0.005 |
0.055± 0.04 |
0.001± 0.001 |
<0.001 | <0.001 | |