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. 2022 Jul 28;14:964336. doi: 10.3389/fnagi.2022.964336

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Copyright © 2022 Tsui, Roy, Chau, Wong, Shi, Poon, Wang, Strekalova, Aquili, Chang, Fung, Song and Lim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A symmetrical Y-maze experiment was conducted with Start Arm (S), Familiar Arm (F), Novel Arm (N). 5xFAD mice showed (A) significantly decreased proportion of time spent (%) in the novel arm, (B) significantly decreased frequency of visits to the novel arm, (C) no significant difference in the distance traveled compared to wildtype mice, (D) significantly increased escape latency (s) on days 2, 4, and 7, but no significant differences on days 1, 3, and 6, (E) significant decreased frequency to enter the target quadrant and time spent on the platform in the long-term memory probe test, and (F) no significant difference in the short-term memory probe test.