Fig. 3.
UPR signaling in fasted-fed Ficfl/fl and Fic−/− pancreata. (A–F) Quantification of BiP, ATF4, Xbp1s, Chop, ATF3, and Fgf21 mRNA analyzed by qPCR from Ficfl/fl (blue bar) and Fic−/− (orange bar) mouse pancreas after fasting, fast-feeding, and fast-feed-recovery. Expression values were normalized to that of the housekeeping gene U36B4. Bars indicate mean relative expression compared to fasted controls, and error bars represent SE. Statistics were performed using GraphPad Prism 9 using a two-way ANOVA. n = 8. *P < 0.05; **P < 0.01.