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. 2022 Aug 5;119(32):e2201151119. doi: 10.1073/pnas.2201151119

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Copyright © 2022 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 5. — Knocking out BDNF from hippocampal excitatory neurons reduced KA-induced seizures. (A) AAV-CaMKII-mCherry (control) or AAV-CaMKII-Cre-mCherry (cKO) was injected bilaterally into ventral and dorsal DG of Bdnf^fl/fl mice. (B) Representative confocal images (Left) and quantification (Right) showing high viral expression in the DG. Control (Ctrl) vs cKO. (C–E) Deletion of BDNF from hippocampal excitatory neurons (Bdnf^fl/fl mice injected with AAV-CaMKII-Cre-mCherry) induced significant decreases in the cumulative seizure score (C) and in the sum score (D) and a significantly increase in latency to convulsive seizures (E) as compared with controls (Bdnf^fl/fl mice injected with AAV-CaMKII-mCherry). *P < 0.05. Data are presented as mean ± SEM.