Table 2.
Pooled summary for the association of comorbidities with COVID-19 infection
| Comorbidity | No. of included studies/total studies | Group n/N | OR (95% CI) | p-value | 95% prediction interval | ||
|---|---|---|---|---|---|---|---|
|
|
|
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| COVID-19 positive | COVID-19 negative | UL | LL | ||||
| Underweight | 1/16 | 2/449 | 1759/348 149 | 0.88 (0.22, 3.54) | 0.858 | - | - |
|
| |||||||
| Overweight | 2/16 | 272/650 | 148 610/348 350 | 1.58 (0.65, 3.86) | 0.314 | - | - |
|
| |||||||
| Obesity | 1/16 | 158/449 | 82 770/348 149 | 1.74 (1.43, 2.11) | <0.001 | - | - |
|
| |||||||
| Diabetes | 8/16 | 1013/3308 | 331 477/358 939 | 1.14 (0.72, 1.82) | 0.579 | 0.23 | 5.74 |
|
| |||||||
| Hypertension | 7/16 | 1045/2859 | 3615/10 826 | 0.99 (0.70, 1.43) | 0.982 | 0.32 | 3.12 |
|
| |||||||
| High cholesterol | 2/16 | 510/2246 | 1851/10 209 | 0.95 (0.56, 1.63) | 0.780 | 0.02 | 46.65 |
|
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| Cardiovascular disease | 4/16 | 60/550 | 47/416 | 1.20 (0.39, 3.72) | 0.754 | 0.01 | 159.25 |
|
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| Depression | 1/16 | 73/782 | 141/7025 | 0.96 (0.56, 1.63) | 0.866 | - | - |
|
| |||||||
| Schizophrenia | 1/16 | 15/782 | 427/7025 | 0.56 (0.37, 0.82) | 0.003 | - | - |
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| Dementia | 1/16 | 27/782 | 1172/7025 | 0.56 (0.43, 0.71) | <0.001 | - | - |
|
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| Coronary artery disease | 2/16 | 77/847 | 946/7090 | 0.64 (0.46, 0.87) | 0.005 | - | - |
|
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| Chronic lung disorder | 4/16 | 272/1245 | 1920/7488 | 1.26 (0.99, 1.61) | 0.055 | 0.63 | 2.54 |
|
| |||||||
| Townsend deprivation quintile | |||||||
| 1 | 1/16 | 61/449 | 70 726/348 149 | 0.62 (0.47, 0.81) | <0.001 | - | - |
| 2 | 1/16 | 76/449 | 70 644/348 149 | 0.80 (0.62, 1.02) | 0.075 | - | - |
| 3 | 1/16 | 64/449 | 70 270/348 149 | 0.65 (0.50, 0.85) | 0.002 | - | - |
| 4 | 1/16 | 105/449 | 65 840/348 149 | 1.21 (0.97, 1.50) | 0.092 | - | - |
| 5 | 1/16 | 143/449 | 65 840/348 149 | 2.00 (1.64, 2.44) | <0.001 | - | - |
COVID-19, coronavirus disease 2019; n, number of patients with the comorbidity; N, total patients in the group; OR, odds ratio; CI, confidence interval.