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. 2022 Aug 4;2022:8172866. doi: 10.1155/2022/8172866

Figure 2.

Figure 2

Apigenin can attenuate cell proliferation and migration in cSCC cells. (a) CCK-8 assay was implied to analyze the cell viability after the treatment of TPA-induced JB6 and A431 cells with different concentrations of apigenin (up to 80 μM) as time gone (mean values ± SEM, n = 6). ∗∗∗∗p < 0.0001vs. control by ANOVA. (b) Representative images of colony formation assay in TPA-induced JB6 treated with control (DMSO) or 80 μM apigenin. (c) Typical pictures (left) and quantitative analysis (right) of wound healing assay in TPA-induced JB6 (up) and A431 (down) cells. Cells were treated with control (DMSO) or 80 μM apigenin for indicated time points. ns: no statistical significance; ∗∗∗∗p < 0.0001vs. control by Student's unpaired t-test.