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. 2022 Jul 25;50(14):8240–8261. doi: 10.1093/nar/gkac631

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — The eIF4F complex discriminates eIF4E–mRNA interaction dynamics in an ATP-dependent manner. (A) Representative single-molecule fluorescence trace for eIF4E–mRNA interaction in the eIF4F complex without added ATP, on NCE102. (B) Representative trace for eIF4E–mRNA binding in the eIF4F complex with ATP, on NCE102. (C) eIF4E–mRNA association rates for the eIF4F complex without ATP (red), compared with the rates in the presence of eIF4E only (grey). (D) Dissociation rates of transient eIF4E–mRNA interactions in the eIF4F complex without ATP. (E) Dissociation rates of long-lived eIF4E–mRNA interactions in the eIF4F complex without ATP. (F) eIF4E–mRNA association rates in the eIF4F complex with ATP (red), compared with the rates in the presence of eIF4E only. (G) Dissociation rates of transient eIF4E–mRNA interactions in the eIF4F complex with ATP. (H) Dissociation rates of long-lived eIF4E–mRNA interactions in the eIF4F complex with ATP.