Table 1.
Consensus ranks of transcriptome perturbation across three different analytical metrics
| Tissue | Time | Cell type | ED | SVM | Subset DEG | Avg rank |
|---|---|---|---|---|---|---|
| Blood | 24-h | CD8+ T cells | 3 | 1 | 1 | 1.67 |
| Blood | 24-h | CD4+ T cells | 2 | 5 | 1 | 2.67 |
| Blood | 24-h | Ly6c+ monocytes | 5 | 3 | 3 | 3.67 |
| Blood | 7-day | CD8+ T cells | 4 | 1 | 1 | 2.00 |
| Blood | 7-day | Ly6c+ monocytes | 3 | 2 | 3 | 2.67 |
| Blood | 7-day | B cells | 1 | 3 | 5 | 3.00 |
| Frontal cortex | 24-h | Astrocytes | 1 | 2 | 1 | 1.33 |
| Frontal cortex | 24-h | Layer 2/3 neurons | 8 | 1 | 2 | 3.67 |
| Frontal cortex | 24-h | Endothelial | 2 | 6 | 4 | 4.00 |
| Frontal cortex | 7-day | Endothelial | 2 | 7 | 5 | 4.67 |
| Frontal cortex | 7-day | Astrocytes | 1 | 8 | 5 | 4.67 |
| Frontal cortex | 7-day | Activated microglia | 3 | 11 | 2 | 5.33 |
| Hippocampus | 24-h | Astrocytes | 1 | 1 | 1 | 1.00 |
| Hippocampus | 24-h | Activated microglia | 2 | 4 | 2 | 2.67 |
| Hippocampus | 24-h | Microglia | 5 | 5 | 3 | 4.33 |
| Hippocampus | 7-day | Oligodendrocytes | 1 | 1 | 5 | 2.33 |
| Hippocampus | 7-day | Astrocytes | 4 | 2 | 2 | 2.67 |
| Hippocampus | 7-day | Choroid plexus epithelial | 6 | 5 | 2 | 4.33 |
Ranks are calculated within tissue and timepoint. Top 3 cell types are displayed for each tissue and timepoint
ED: Euclidean distance; SVM: support vector machine; DEG: differentially expressed genes