REAGENT or RESOURCE	SOURCE	IDENTIFIER
Biological samples
Human sera	COVIDsortium Healthcare Workers bioresource	NCT04318314
Chemicals, peptides, and recombinant proteins
Wuhan Hu-1 SARS-CoV-2 spike protein (S1)	Genscript	Z03501
Alpha VOC B.1.1.7 SARS-CoV-2 (2019-nCoV) Spike S1 (HV69-70 deletion, N501Y, D614G)-His Recombinant Protein	Sino biological	40591-V08H7
Beta VOC B.1.1351 SARS-CoV-2 Spike protein (S1, E484K, K417N, N501Y, His Tag	Genscript	Z03531-1
Delta VOC B.1.617.2 (T19R, G142D, E156G, 157–158 deletion, L452R, T478K, D614G, P681R) Protein (His Tag)	Sino biological	40591-V08H19
Omicron (B.1.1.529/Omicron) Spike Glycoprotein (S1), Sheep Fc-Tag (HEK293) A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y	Native antigen	REC32006-100
IgG protein standard	Sigma Aldrich	I4506
Critical commercial assays
Cobas® SARS-CoV-2 reverse transcriptase polymerase chain reaction (RT-PCR) test	ROCHE	09425217001A-01
Anti-SARS-CoV-2 ELISA	EUROIMMUN	EI 2606–9601 G
Elecsys® Anti-SARS-CoV-2	ROCHE	09 203 095 190
Deposited data
Panorama database	https://panoramaweb.org	SARCOV2immunocomplex
Mendeley Data	https://doi.org/10.17632/csx49c78c6.2	This paperMendeley Data, v2
Software and algorithms
Skyline open source software V.21.2	MacLean B, Tomazela DM, Shulman N, Chambers M, Finney GL, Frewen B, Kern R, Tabb DL, Liebler DC, MacCoss MJ. Skyline: an open source document editor for creating and analyzing targeted proteomics experiments. Bioinformatics. 2010 Apr 1;26(7):966–8. https://doi.org/10.1093/bioinformatics/btq054. Epub 2010 Feb 9. PMID: 20147306; PMCID: PMC2844992.	https://skyline.ms/project/home/software/Skyline/begin.view
Graphpad Prism v9	www.graphpad.com	www.graphpad.com/scientific-software/prism/