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. 2022 Aug 11;13:4709. doi: 10.1038/s41467-022-32138-x

Fig. 1. Loss of Tet family genes leads to cleidocranial dysplasia-like phenotype.

Fig. 1

a Gross images of indicated genotype mice. Scale bar = 5 mm. b The whole mount skeleton staining of WT and indicated genotype mice by Alcian blue and Alizarin red S at postnatal day 0 (P0). The quantification data of the unmineralized area was annotated below the cranial bones. scale bar = 5 mm. c–g Quantification of the length of clavicle (c), femur (d), tibia (e), radius (f), and humerus (g) of indicated genotype mice. *P < 0.05, **P < 0.01. Ordinary one-way ANOVA. Data are presented as mean ± s.d., WT mice = 7, TCKO mice = 5, Prx1-Cre; Tet1 f/+ Tet2 f/f Tet3 f/f mice=3, Prx1-Cre; Tet1 f/f Tet2 f/+ Tet3 f/f mice = 3, Prx1-Cre; Tet1 f/f Tet2 f/f Tet3 f/+ mice = 4 biologically independent animals. h 3D μ-CT images of cranial bones isolated from indicated genotype mice at postnatal day 10 (P10). Representative images are from two independent samples. i Quantification of the unmineralized area of cranial bones in h. n = 2 biologically independent animals.