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. 2022 Jul 4;47(10):1816–1825. doi: 10.1038/s41386-022-01371-9

Fig. 4. Repeated METH alters the firing frequency of interneurons in the mPFC.

Fig. 4

A Schematic representation of intracranial injection of pAVV-FLEX-tdTomato in the mPFC to label parvalbumin-positive interneurons (PV + FSIs). B Colocalization of PV (green) and pAVV-FLEX-tdTomato (red) show selectivity for labeling PV + FSIs (yellow). C Rats treated with repeated METH exhibit a significant increase in PV + FSIs intrinsic excitability [Main effect of drug treatment, Two-way ANOVA, F(1,400) = 77.37, ****p < 0.0001, SAL ncells/rats = 17/8; METH ncells/rats = 10/7]. Representative traces are shown to the right. The schematic illustration was created with BioRender.com.