Table 1.

Behavioral liabilities mediate the association between The Addiction-Risk-Factor and psychiatric factors.

	F1 Indirect %	F1 Indirect P	F2 Indirect %	F2 Indirect P	F3 Indirect %	F3 Indirect P
No covariates
Executive function	0.007	0.463	0.051*	0.001*	0.003	0.486
Neuroticism	0.005	0.842	0.003	0.836	0.013	0.777
Risk-taking	−0.090*	0.001*	0.152*	1.47E−08*	0.043*	0.013*
Controlling for genetics of substance use
Executive function	0.013	0.233	0.048*	0.047*	−0.007	0.491
Neuroticism	0.011	0.687	−0.022	0.693	−0.040	0.689
Risk-taking	0.001	0.509	0.019	0.446	−0.002	0.741

Indirect associations from a mediation model (see Supplementary Fig. 8) where stage-based constructs link non-substance psychopathology (three factors from Lee et al.,) and The Addiction-Risk-Factor. F1 = compulsive disorders, F2 = Psychotic disorders, F3 = Neurodevelopmental disorders. The proportion accounted for by the indirect association (%) and the significance of the indirect association are shown. *P <0 .05 for the indirect association pathway.