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. 2022 Aug 11;12:330. doi: 10.1038/s41398-022-02103-9

Fig. 2. A single high dose or microdosing psilocybin does not have an effect on body weight or food intake in mouse models of obesity.

Fig. 2

A Schematic for single injection study in diet-induced obese (DIO) mice (n = 8 per group). B Body weight in the 12-day period following injection of psilocybin (3 mg/kg) or vehicle. C Cumulative food intake in the 12 days following injection of psilocybin or vehicle. D Schematic for single injection study in ob/ob mice (n = 7–9 per group). E Body weight. F Cumulative food intake. G Schematic for microdosing study in DIO mice. Mice were injected daily with psilocybin (0.3 mg/kg; n = 7) or vehicle (n = 6). H Body weight following daily injection of psilocybin (0.3 mg/kg) or vehicle for 7 days (n = 6/7 per group). I Food intake. J Schematic for microdosing study in MC4R KO mice (n = 8 per group). K Body weight. L Food intake. Data are presented as mean ± SEM (analyzed by RM two-way ANOVA with Bonferroni’s test).