Table 1.
Demographics.
| Group | Sex | Age (years) | Race | Ethnic origin | Employment status | Marital/relationship status | Estimated illness duration (years) | Baseline HAMD-17 item | Baseline PHQ-9 | Past antidepressant trials | Past psychotherapy | Education (years) | Weekly alcohol intake (units) | Previous psychedelic use (time since last use) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | HC | M | 58 | Asian | Non-Hispanic | Employed | Married | N/A | N/A | N/A | N/A | N/A | >17 | 7 | None |
| 2 | HC | M | 24 | Asian | Non-Hispanic | Student | Single | N/A | N/A | N/A | N/A | N/A | 17 | 0 | Psilocybin (3 years ago) |
| 3 | HC | M | 24 | White | Non-Hispanic | Employed | Domestic partnership | N/A | N/A | N/A | N/A | N/A | 16 | 2 | None |
| 4 | MDD | F | 43 | White | Non-Hispanic | Employed | Single | 22 | 22 | 22 |
SSRI × 3 SNRI × 2 Atypical antidepressant × 1 |
Yes | >17 | 0 | MDMA (10+ years ago) |
| 5 | MDD | F | 59 | White | Non-Hispanic | Unemployed | Married | 20+ | 25 | 22 |
SSRI × 3 SNRI × 3 TCA × 2 Atypical antidepressant × 2 |
Yes | >17 | 0 | None |
| 6 | MDD | M | 31 | White | Non-Hispanic | Employed | Married | 25 | 18 | 19 |
SSRI × 1 Atypical antidepressant × 1 |
Yes | >17 | 0 | Psilocybin (6 weeks ago) |
| 7 | MDD | M | 59 | White | Non-Hispanic | Employed | Married | 20+ | 28 | 14 |
SSRI × 4 SNRI × 2 SGA × 1 Atypical antidepressant × 2 Mood stabilizer × 1 Ketamine × 1 ECT × 1 |
Yes | >17 | 0 | None |
| 8 | MDD | F | 46 | White | Non-Hispanic | Unemployed | Married | 20+ | 22 | 21 |
SSRI × 2 Atypical antidepressant × 1 |
Yes | 16 | 2 | Psilocybin (>20 years) |
| 9 | MDD | M | 38 | Asian | Non-Hispanic | Employed | Single | 29 | 31 | 22 |
SSRI × 5 TCA × 1 Atypical antidepressant × 2 Stimulant × 2 SGA × 4 Mood stabilizer × 2 Ketamine × 1 ECT × 1 |
Yes | >17 | 1 | Psilocybin (10 years) LSD (5 years) |
| 10 | MDD | M | 53 | White | Non-Hispanic | Employed | Married | 20+ | 21 | 18 |
SSRI × 3 SNRI × 1 Mood stabilizer × 2 Atypical antidepressant × 2 |
Yes | 12 | 0 | LSD (30 years) |
N/A not applicable, HC healthy control, MDD major depressive disorder, M male, F female, SSRI selective serotonin reuptake inhibitor, SNRI serotonin norepinephrine reuptake inhibitor, TCA tricyclic antidepressant, ECT electro convulsive treatment, SGA second-generation antipsychotic, LSD lysergic acid diethylamide.