Table 2.
Adverse events.
| Subject no. | Group | DMT dose (mg/kg) | Adverse event | Severity | Onset relative to DMT administration (min) | Duration | Comment |
|---|---|---|---|---|---|---|---|
| 1 | Healthy | 0.1 | Headache | Mild | +45 | 5 hours | |
| 0.3 | Hypertension | Moderate | +5 | 5 minutes | |||
| 2 | 0.1 | – | – | – | – | ||
| 0.3 | Ringing sensation in the ears | Mild | +3 | 5 minutes | |||
| 3 | 0.1 | Anxiety | Mild | –30 | 40 minutes | Anticipatory | |
| Lightheadedness | Mild | +1 | 10 minutes | ||||
| 0.3 | Lightheadedness | Mild | +1 | 15 minutes | |||
| Tachycardia and subjective feeling of palpitation | Mild | +1 | 5 minutes | ||||
| 4 | Major depressive disorder | 0.1 | Anxiety | Mild | 0 | 10 minutes | |
| 0.3 | Back pain | Mild | The day after the test day, right after a moderately intense physical activity, improved with rest and nonsteroidal anti-inflammatory use | Significantly improved within 24 h, completely subsided within a week. | History of back pain | ||
| 5 | 0.1 | Headache | Mild | +1 | 20 seconds | ||
| 0.3 |
Hypotension (asymptomatic) See supplementary for details |
Severea | +2 | 5 minutes | History of reflex syncope | ||
|
Bradycardia (asymptomatic) See supplementary for details |
Severea | +2 | 5 minutes | History of reflex syncope | |||
| 6 | 0.1 | Nausea | Mild | +4 | 5 minutes | ||
| 0.3 | Nausea | Mild | +2 | 5–10 min | |||
| 7 | 0.1 | – | – | – | – | ||
| 0.3 | Anxiety | Mild | +2 | 60 minutes | |||
| Dysphoria | Mild | +5 | 24 hours | ||||
| 8 | 0.1 | Tingling | Mild | +3 | 15 minutes | ||
| 0.3 | – | – | – | – | |||
| 9 | 0.1 | Anxiety | Mild | +2 | 30 minutes | ||
| 0.3 | Anxiety | Mild | −20 | 60 minutes | Anticipatory | ||
| 10 | 0.1 | Anxiety | Mild | −30 | 30 minutes | Anticipatory | |
| Hypertension | Mild | −30 | 20 minutes |
aSee Supplementary S6 for details.