Table 2.
MMN amplitude | ASSRa (40 Hz stimulation) | Resting state power in gamma band | ||||||
---|---|---|---|---|---|---|---|---|
Duration (µV) | Frequency (µV) | Duration + frequency (µV) | Induced power (dB) | Evoked power (dB) | Phase-locking factor | Absolute power (µV2) | Relative power (%) | |
Total patients (N = 79) | ||||||||
Nb | 47 | 46 | 47 | 37 | 57 | |||
Mean | −0.02 | 0.17 | −0.10 | 0.15 | −0.09 | −0.00 | −0.02 | −0.23 |
SEM | 0.21 | 0.20 | 0.25 | 0.20 | 1.20 | 0.01 | 0.26 | 0.25 |
SD | 1.41 | 1.33 | 1.70 | 1.20 | 7.27 | 0.07 | 1.93 | 1.88 |
Min | −2.54 | -3.21 | −4.89 | −1.87 | −12.21 | −0.13 | −6.21 | −11.52 |
Max | 3.31 | 3.23 | 3.28 | 4.03 | 13.02 | 0.19 | 10.29 | 4.81 |
Placebo (N = 20) | ||||||||
Nb | 12 | 10 | 15 | |||||
Mean | −0.22 | 0.68 | 0.29 | 0.26 | 0.79 | 0.01 | −0.76 | −0.46 |
SEM | 0.40 | 0.47 | 0.61 | 0.45 | 2.25 | 0.03 | 0.28 | 0.25 |
SD | 1.38 | 1.62 | 2.11 | 1.42 | 7.13 | 0.08 | 1.10 | 0.96 |
Min | −2.18 | −2.17 | -3.82 | −1.87 | −10.91 | −0.07 | −3.97 | −3.20 |
Max | 1.70 | 2.94 | 3.28 | 3.41 | 11.83 | 0.19 | 0.83 | 1.23 |
Iclepertin 10 + 25 mg (N = 35) | ||||||||
Nb | 21 | 15 | 26 | |||||
Mean | −0.01 | 0.33 | -0.08 | 0.01 | −2.09 | −0.01 | 0.24 | −0.43 |
SEM | 0.30 | 0.23 | 0.40 | 0.20 | 1.78 | 0.02 | 0.50 | 0.47 |
SD | 1.36 | 1.05 | 1.84 | 0.76 | 6.90 | 0.06 | 2.56 | 2.41 |
Min | −2.54 | −1.59 | −4.89 | −1.53 | −12.21 | −0.13 | −6.21 | −11.52 |
Max | 1.72 | 3.23 | 2.79 | 0.99 | 12.33 | 0.09 | 10.29 | 2.15 |
ASSR auditory steady-state response, CfBchange from baseline; EEG electroencephalography; EoT end of treatment, MMN mismatch negativity, SD standard deviation; SEM standard error of the meanASSR, auditory steady-state response; CfB change from baseline, EEG electroencephalography, EoT end of treatment, MMN mismatch negativity, SD standard deviation, SEM standard error of the mean.
aBaseline-corrected.
bNumber of patients with analyzable data for each EEG parameter.