Fig. 4. Prenatal opioid exposure prevents extinction of oxycodone-conditioned place preference in adult male, but not female, offspring.

A Schematic of conditioned place preference procedure. B In males, a significant interaction effect was observed between treatment and session. Posthoc testing revealed significant group differences such that control male offspring showed a significantly lower preference for the drug-paired compartment on extinction session 1 as compared to the test session, while no decrease between test and extinction 1 was observed in oxycodone-exposed males. C Both control and oxycodone-exposed females showed extinction of conditioned place preference. Data represent Mean +/− SEM, *p = 0.05 relative to Test session.