Table 1.

Hazard ratio (HR) performance in the four testing datasets.

Dataset	Prostate cancer type	HRs and 95% CI
		HR20/50	HR80/50	HR95/50	HR80/20
ProtecT n = 6411	Any	0.31 [0.30–0.32]	3.47 [3.36–3.58]	5.93 [5.67–6.21]	11.16 [10.48–11.88]
	Clinically significant	0.28 [0.27–0.30]	3.86 [3.67–4.06]	6.91 [6.42–7.44]	13.73 [12.43–15.16]
African n = 6253	Any	0.43 [0.42–0.45]	2.58 [2.50–2.67]	3.69 [3.52–3.86]	5.95 [5.59–6.34]
	Clinically significant	0.40 [0.39–0.41]	2.82 [2.72–2.93]	4.33 [4.10–4.57]	7.07 [6.58–7.60]
Asian n = 2378	Any	0.34 [0.33–0.35]	2.99 [2.89–3.08]	5.08 [4.85–5.33]	8.75 [8.21–9.32]
	Clinically significant	0.31 [0.30–0.33]	3.24 [3.12–3.36]	5.66 [5.46–5.98]	10.31 [9.58–11.11]
COSM n = 3279	Any	0.33 [0.32–0.34]	3.54 [3.42–3.65]	5.77 [5.51–6.04]	10.87 [10.21–11.57]
	Clinically significant	0.32 [0.31–0.33]	3.59 [3.45–3.75]	5.91 [5.58–6.26]	11.18 [10.34–12.09]
	Fatal	0.38 [0.35–0.42]	2.95 [2.68–3.25]	4.49 [3.93–5.13]	7.73 [6.45–9.27]

HRs are shown with mean sample-weight-corrected values and 95% confidence intervals. Calculations were done using age at diagnosis of any or of clinically significant prostate cancer across all datasets, respectively, and also with age at prostate cancer death for the COSM dataset.