Table 2.

Multivariable Cox models with both PHS and family history of prostate cancer (defined as ≥1 first-degree relative affected) for association with any prostate cancer, with clinically significant prostate cancer, and with fatal prostate cancer.

Dataset	Variable	Any prostate cancer
		beta	z-score	p-value	HR
ProtecT (iCOGs), n = 5703	PHS	2.11	72.1	<10−16	8.13
	Family history	0.06	1.7	0.1	1.07
African (OncoArray), n = 5557	PHS	1.64	53.8	<10−16	5.03
	Family history	1.13	46.6	<10−16	3.09
Asian (OncoArray); n = 1028	PHS	1.99	68.5	<10−16	7.64
	Family history	0.45	13.1	<10−16	1.56
COSM (OncoArray), n = 2453	PHS	2.13	71.2	<10−16	8.71
	Family history	0.53	19.0	<10−16	1.70
Dataset	Variable	Clinically significant prostate cancer
		beta	z-score	p-value	HR
ProtecT (iCOGs), n = 5703	PHS	2.32	49.8	<10−16	10.01
	Family history	−0.01	−0.2	0.82	0.99
African (OncoArray), n = 5557	PHS	1.67	37.4	<10−16	5.19
	Family history	1.17	33.2	<10−16	3.22
Asian (OncoArray), n = 1028	PHS	1.89	50.4	<10−16	6.90
	Family history	0.13	2.5	0.012	1.14
COSM (OncoArray), n = 2453	PHS	2.13	56.9	<10−16	6.90
	Family history	0.45	12.6	<10−16	1.57
Dataset	Variable	Fatal prostate cancer
		beta	z-score	p-value	HR
COSM (OncoArray), n = 2453	PHS	1.68	19.8	<10−16	5.51
	Family history	0.43	5.0	4.7 × 10−7	1.53

Analyses were limited to participants with known family history. Beta and z-scores refer to the overall association (within the multivariable Cox regression) with the endpoint of interest, within the corresponding testing dataset. The p-values reported are two-tailed from the multivariable Cox models.