Table 2.
Effect of dry bearberry leaves extracts on HOMA-IR in a model of insulin-resistance induced by dexamethasone injections in rats
Indices | Time period | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Initial | 5 weeks | 7 weeks/experimental groups | ||||||||
IC | Dex | IC | Dex | Dex_PE50 | Dex_PE50_cys | Dex_cys | Dex_met | Dex_arph | ||
Glucose, mmol/L | 4.15 ± 0.28 | 4.03 ± 0.41 | 5.93 ± 0.63* | 3.95 ± 0.27 | 7.58 ± 0.91* | 5.81 ± 0.54*/# | 5.37 ± 0.49# | 6.01 ± 0.47* | 5.33 ± 0.31*/# | 6.11 ± 0.47* |
IRI, pmol/L | 73 ± 7 | 72 ± 8 | 105 ± 8* | 74 ± 9 | 121 ± 15* | 91 ± 9* | 82 ± 7*/# | 90 ± 9* | 71 ± 6*/# | 95 ± 10 |
HOMA | 1.9 ± 0.6 | 1.8 ± 0.6 | 4.0 ± 0.8*/# | 1.7 ± 0.6 | 5.9 ± 0.9 | 3.4 ± 0.6*/# | 2.8 ± 0.3# | 3.5 ± 0.2 | 2.4 ± 0.2 | 3.7 ± 0.4 |
Each value represents the mean ± standard error (n = 6)
*Indicates significant difference relative to IC group (p ≤ 0.05)
#Indicates significant difference relative to Dex group (p ≤ 0.05)