Table 3.
Stratified associations of blood chloroform on PSA in the prespecified and exploratory subgroup.
| Blood Chloroform | N | Model 1 β (95% CI) P | Model 2 β (95% CI) P | Model 3 β (95% CI) P |
|---|---|---|---|---|
| Stratified by age | ||||
| <60 | 1170 | 0.000 (−0.002, 0.002) 0.8393 | 0.000 (−0.002, 0.002) 0.8041 | −0.000 (−0.002, 0.002) 0.8647 |
| 60–69 | 363 | 0.050 (0.035, 0.065) <0.0001 | 0.049 (0.034, 0.065) <0.0001 | 0.060 (0.040, 0.080) <0.0001 |
| 70–79 | 292 | 0.005 (−0.021, 0.032) 0.6855 | 0.007 (−0.020, 0.034) 0.6012 | 0.001 (−0.060, 0.062) 0.9720 |
| ≥80 | 23 | −0.043 (−0.113, 0.027) 0.2378 | −0.016 (−0.111, 0.078) 0.7419 | NA |
| Stratified by race | ||||
| Hispanic | 445 | −0.002 (−0.008, 0.003) 0.3444 | −0.001 (−0.006, 0.004) 0.6431 | −0.001 (−0.006, 0.004) 0.7159 |
| Non-Hispanic White | 940 | −0.001 (−0.007, 0.005) 0.6943 | 0.002 (−0.003, 0.008) 0.4284 | 0.002 (−0.005, 0.009) 0.5653 |
| Non-Hispanic Black | 3801 | 0.036 (0.025, 0.047) <0.0001 | 0.035 (0.024, 0.045) <0.0001 | 0.055 (0.041, 0.070) <0.0001 |
| Other race/ethnicit | 83 | −0.022 (−0.053, 0.009) 0.1745 | −0.010 (−0.036, 0.016) 0.4362 | −0.021 (−0.059, 0.018) 0.3109 |
| Stratified by education | ||||
| Less than high school | 554 | −0.002 (−0.009, 0.006) 0.6716 | 0.000 (−0.007, 0.007) 0.9282 | 0.000 (−0.008, 0.009) 0.9153 |
| High school | 457 | −0.001 (−0.008, 0.005) 0.6406 | 0.002 (−0.004, 0.008) 0.4545 | 0.005 (−0.004, 0.014) 0.2980 |
| More than high school | 837 | 0.021 (0.015, 0.027) <0.0001 | 0.022 (0.017, 0.028) <0.0001 | 0.027 (0.021, 0.033) <0.0001 |
| Stratified by ratio of family income | ||||
| Low | 608 | −0.001 (−0.008, 0.005) 0.6947 | 0.000 (−0.006, 0.007) 0.9685 | −0.000 (−0.008, 0.007) 0.9090 |
| Middle | 624 | −0.004 (−0.013, 0.005) 0.3821 | −0.001 (−0.009, 0.008) 0.8989 | 0.001 (−0.009, 0.010) 0.9047 |
| High | 616 | 0.017 (0.011, 0.023) <0.0001 | 0.018 (0.013, 0.023) <0.0001 | 0.031 (0.024, 0.038) <0.0001 |
| Stratified by BM | ||||
| <25 | 409 | −0.002 (−0.017, 0.012) 0.7515 | 0.001 (−0.013, 0.016) 0.8670 | 0.005 (−0.015, 0.026) 0.6111 |
| 25–28 | 467 | 0.009 (0.004, 0.015) 0.0006 | 0.011 (0.006, 0.016) <0.0001 | 0.011 (0.005, 0.016) 0.0001 |
| >28 | 942 | 0.000 (−0.005, 0.005) 0.9477 | 0.002 (−0.003, 0.007) 0.3938 | 0.004 (−0.003, 0.011) 0.2411 |
Note 1: Model 1: Non-adjusted model adjusts for none. Model 2: Minimally adjusted model adjusts for age, race/ethnicity, education level, marital status and poverty to income ratio. Model 3: Fully adjusted model adjusted age, race/ethnicity, education level, marital status, poverty to income ratio, BMI (kg/m2), Had at least 12 alcohol drinks/1 year, smoked at least 100 cigarettes in life, diabetes, physical activity (MET-based rank) (%), blood urea nitrogen, uric acid, creatinine.
Note 2: In each case, the model was not adjusted for the stratification variable itself. Bold values means statistically significant.