Table 4.
Prognostic factors identified via multivariate analysis for metastatic renal cell carcinoma in patients with liver metastases.
| Study | Year | Study Description | Patient # | Prognostic Factors | Endpoint HR/OR (95% CI) | p-value |
|---|---|---|---|---|---|---|
| Thelen et al. | 2007 | Retrospective, Single-center | 31 | Resection margins | OS Not Recorded | 0.005 |
| Staehler et al. | 2010 | Retrospective, Single-center | 88 | Fuhrman grade | OS HR 2.568 (1.238–5.329) | 0.011 |
| Initial T-stage | OS HR 3.712 (1.440–9.552) | 0.007 | ||||
| ECOG PS ≥1 | OS HR 3.763 (1.777–7.972) | 0.001 | ||||
| Liver MTX | OS HR 2.230 (1.054–4.719) | 0.036 | ||||
| Kim et al. | 2019 | Retrospective, Single-center | 273 | Concomitant Liver + Lung Metastasis | PFS HR 2.22 (1.07–4.58) | 0.0320 |
| OS HR 2.62 (1.23–5.58) | 0.0126 | |||||
| Beetz et al. | 2020 | Retrospective, Single-center | 40 | Multivisceral resection | OS HR 9.851 (2.715–35.737) | 0.001 |
| Longer interval from nephrectomy to hepatic MTX | OS HR 0.971 (0.956–0.987) | <0.001 |
HR, hazard ratio; OR, odds ratio; OS, overall survival; PFS, progression-free survival; ECOG PS, Eastern Cooperative Oncology Group Performance Status; MTX, metastasectomy.