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Molecular Therapy logoLink to Molecular Therapy
. 2022 Jul 6;30(8):2869–2873. doi: 10.1016/j.ymthe.2022.06.020

Base-edited cynomolgus monkeys mimic core symptoms of STXBP1 encephalopathy

Zongyang Lu, Siting He, Jian Jiang, Ling Zhuang, Yan Wang, Guang Yang, Xiaoyu Jiang, Yanhong Nie, Jiqiang Fu, Xiaotong Zhang, Yong Lu, Xinyan Bian, Hung-Chun Chang, Zhiqi Xiong, Xingxu Huang , Zhen Liu ∗∗, Qiang Sun ∗∗∗
PMCID: PMC9372315  PMID: 35797994

Main Text

(Molecular Therapy, 30, 2163–2175; June 2022)

In the originally published version of this article, the authors made errors in the graphical abstract and Figure 1A. Both in the graphical abstract and Figure 1A, the substituted bases in plus and minus strand were incorrectly shown.

Additionally, the citation to Figure 4A in the sentence “Scalp EEG recordings from A1 during 3–4 months postpartum showed a typical suppression-burst pattern in addition to interictal epileptiform discharges (Figures 4A)” has been corrected to “Figure 2A.” The citation to Figure 4D in the sentence “Only one C-to-T substitution (chr8: 43865425) observed in B2 was identified as a sgRNA-dependent off-target (Figure 4D)” has been corrected to “Figure 4F.” These errors have been corrected online.

The authors regret these errors.

Figure 1.

Figure 1

A3A-mediated C-to-T substitutions at the STXBP1 locus in nonhuman primates (corrected)

Figure 1.

Figure 1

A3A-mediated C-to-T substitutions at the STXBP1 locus in nonhuman primates (original)

graphic file with name fx1c.jpg

Graphical abstract (corrected)

graphic file with name fx1o.jpg

Graphical abstract (original)

Contributor Information

Xingxu Huang, Email: huangxx@shanghaitech.edu.cn.

Zhen Liu, Email: zliu2010@ion.ac.cn.

Qiang Sun, Email: qsun@ion.ac.cn.


Articles from Molecular Therapy are provided here courtesy of The American Society of Gene & Cell Therapy

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