Angiotensin II and endothelin-1 induce IL-15 signaling
(A and B) The levels of angiotensin II (Ang II) and endothelin-1 (ET-1) in the renal cortex from ADR-treated mice (A, n = 9) and db/db mice (B, n = 8).
(C) Correlation between Ang II and IL-15 in renal cortex of ADR-treated and db/db mice (n = 8). R, Pearson correlation coefficient. (D) Correlation between ET-1 and IL-15 in renal cortex of ADR-treated and db/db mice (n = 8). R, Pearson correlation coefficient. (E) The secretion of IL-15 in primary renal parenchymal cells after Ang II (10−6 mol/L) or ET-1 (10−6 mol/L) treatment (n = 6).
(F and G) The level of IL-15 in renal cortex of ADR-treated mice (F, n = 8) and db/db mice (G, n = 6). Data are represented as mean ± SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.