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. 2022 Jul 29;13:962912. doi: 10.3389/fimmu.2022.962912

Figure 4.

Figure 4

Effect of early ART initiation on FoxP3+ CD8 T-cells potential migration. (A) Gating strategies used in flow cytometry to define CD8+FoxP3+ T-cells -expressing CCR4, CCR5, CCR6, CXCR3, Integrin-β7 and CCR9. Frequencies of CD8+FoxP3+CCR4+ (B), CD8+FoxP3+CCR5+ (C), CD8+FoxP3+CCR6+ (D), CD8+FoxP3+CXCR3+ (E), CD8+FoxP3+Integrin-β7+ (F), and CD8+FoxP3+CCR9+ (G) within CD8 T-cells. Statistical significance is indicated in the figures as follow: *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. Differences among five study groups was determined by nonparametric Mann-Whitney rank test for unpaired variables, while the Wilcoxon rank tests were used for paired variables in the longitudinal study. Sample size in cross-sectional analysis: non-infected n=20, Acute n=26, Chronic ART- n=10, Chronic ART+ n=11, EC n=18. Sample size in longitudinal analysis: non-infected n=20, ART- n=10, ART+ n=10.