. 2022 May 31;15(8):2035–2052. doi: 10.1111/cts.13314

TABLE 1.

PermQ model physiological inputs. Blood flows, volumes, and surface areas used as inputs for the PermQ model

	Low perfusion low capillary permeability		Low perfusion high capillary permeability	High perfusion low capillary permeability			High perfusion high capillary permeability				Brain
Parameter	C1	Adipose	C2	C3	Lung	Mesentery	C4	Mucosa	Spleen	Liver	Brain ^a
Q (L/min)	1.359	0.284	0.391	0.335	5.691	0.972	1.188	0.108	0.171	1.451	0.683
Re1	0.780	0.363	1.000	0.491	0.631	0.560	0.476	0.560	0.469	0.534	0.296
Re2	0.350	0.163	0.448	0.220	0.283	0.251	0.213	0.251	0.210	0.239	0.133
V_b (L)	0.405	0.18	0.104	0.094	0.023	0.05	0.084	0.002	0.009	0.079	0.058
V_e (L)	3.55	1.682	1.175	0.506	0.178	0.305	0.426	0.034	0.035	0.293	0.227
V_c (L)	19.30	0.212	4.28	0.72	0.236	0.513	0.753	0.057	0.098	1.043	0.868
V_nl (L)	0.79	10.62	0.201	0.018	0.01	0.038	0.011	0.004	0.001	0.016	0.054
V_pl (L)	0.193	0.016	0.015	0.013	0.005	0.011	0.030	0.0012	0.0015	0.035	0.002
SA_b (10³ dm²)	21.6	9.58	5.54	5.0	4.42	2.64	4.48	0.098	0.46	4.21	3.11
SA_ISF (10³ dm²)	324	144	83.0	75.0	18.4	39.6	67.2	1.47	6.94	500	46.7
SA_nl (10³ dm²)	948	2125	241	21.6	12.1	45.4	13.7	5.04	1.01	19.1	65.2
SA_pl (10³ dm²)	6040	498	470	419	163	335	936	37.2	45.5	1083	52.5

Abbreviations: Q, blood flow; re1, ratio of albumin in ISF outside plasma to total plasma protein; re2, ratio of alpha acid glycoprotein in ISF outside plasma to total plasma protein; SA_b, surface area of blood capillaries; SA_isf, surface area of cells facing the ISF; SA_nl, surface area of neutral lipid membranes; SA_pl, surface area of phospholipid membranes; V_am, volume of the apical membrane; V_b, volume of blood capillaries; V_i, volume of ISF; V_nl, volume of neutral lipids; V_pl, volume of phospholipids.

^{^a}

For brain, V_am (L) = 6.533 × 10⁻⁵ was used.