TABLE 2.
Population parameter estimates
| Theta | Estimate | SE | RSE (%) | Bootstrapping median (95% CI) |
|---|---|---|---|---|
| CL/Fb, L/h | 730 | 164 | 22.5 | 705 (431–1099) |
| V/Fb, L | 610 | 204 | 33.4 | 632 (343–1008) |
| Fv/b | 2.3 | 0.479 | 20.8 | 2.4 (1.63–4.77) |
| ka, 1/h (buccal, 25 μg) | 0.709 | 0.111 | 15.7 | 0.724 (0.54–0.92) |
| ka, 1/h (buccal, 50 μg) | 0.537 | 0.0868 | 16.2 | 0.531(0.37–0.63) |
| ka, 1/h (vaginal, 25 μg) | 0.464 | 0.167 | 36 | 0.507 (0.2–1) |
| ka, 1/h (vaginal, 50 μg) | 0.24 | 0.0694 | 28.9 | 0.246 (0.103–0.453) |
| Vmax/Fb, pg/ml | 5.45 | 0.695 | 12.8 | 5.64 (3.141–10.453) |
| Km, pg | 2.5 | 1.03 | 41.2 | 2.864 (0.73–10.41) |
| Omega | Estimate | SE | RSE (%) | Etabar | p Value | Shrinkage (%) |
|---|---|---|---|---|---|---|
| CL, L/h | 0.602 | 0.203 | 33.7 | 0.01 (0.094) | 0.91 | 15.6 |
| V, L | 1.55 | 0.365 | 23.5 | 0.066 (0.151) | 0.66 | 16 |
| k a, 1/h | 0.0599 | 0.0636 | 106.2 | 0.022 (0.027) | 0.31 | 38.3 |
| IOV | 0.0848 | 0.0511 | 60.3 | −0.043 (0.027) | 0.11 | 39.4 |
| Sigma | Estimate | SE | RSE (%) | Shrinkage (%) |
|---|---|---|---|---|
| PROP | 0.262 | 0.0269 | 10.3 | 9 |
Abbreviations: CI, confidence interval; CL, clearance; CL/Fb, estimated for apparent clearance; IOV, interoccasion variability; ka, absorption rate constant; Km, kinetic metabolite; PROP, proportional error; RSE, relative standard error; V, volume; V/Fb, apparent volume of distribution; Vmax/Fb, apparent maximum velocity of drug clearance following buccal administration.