Figure 6.

Conserved germline contacts of Vβ2 with pMHC. All Vβ2 TCR/pMHC structures are superposed and presented in the same view. Atoms are shown in CPK coloring. Vβ2 residues (28Q and 50R) are shown as pale yellow sticks. (A) The position of Vβ2 28Q from Vβ2 containing TCRs is shown interacting with the MHC α2 helices (or β1 helix from MHC-II) shown in magenta ribbon diagram. (B) The position of Vβ2 50R with pMHC contact from the same structures as in (A). MHC α1 helices are shown in cyan ribbon diagram, peptides are shown in white cartoon, and the residues that interact with TCR are shown as white sticks. Protein Data Bank identifiers are: L^d-HF10 (PDB: 6X31); BM3.3 TCR with K^b-pBM1 (PDB: 1FO0); KB5 TCR with K^b-Pkb1 (PDB: 1JK2); I29 with IA^g7-insulin B:9-23 (PDB: 5JZ4).