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. 2022 Jul 29;14:930105. doi: 10.3389/fnagi.2022.930105

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Copyright © 2022 Guo, Zhang, Zou, Ding, Chen, Pan, Ji, Ye and Xiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Possible mechanisms by which metabolic syndrome (MetS) affects age-related hearing loss (ARHL). Mets may cause signal pathway and related factor changes, such as insulin-like growth factor 1 (IGF-1) (Riquelme et al., 2010; Alassaf et al., 2019), adenosine monophosphate-activated protein kinase (AMPK) (Zhao et al., 2020), sirtuins (Han and Someya, 2013; Hao et al., 2019; Pang et al., 2019; Miwa, 2021), adiponectin (APN) (Liu et al., 2019) and DRP-1 (Lin et al., 2019). These changes lead to mitochondrial changes so that can exacerbate ARHL.