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. 2022 Jul 29;13:928593. doi: 10.3389/fimmu.2022.928593

Figure 1.

Figure 1

miR-144/451 ablation upregulates DCs activation. Frequency of CD11b+CD11c+ DCs in the spleen of WT or miR-144/451 KO mice (A). Expression of CD80, CD86 and CD40 on splenic DCs (B). Intracellular staining of TNF-α and IL-6 on splenic DCs stimulated 5 h with PMA/Ionomycin plus BFA (C). CD8+T cells (D) and CD4+T cells (E) were co-cultured with WT or miR-144/451 KO DCs for 24 h, expression of surface markers CD69, NKG2D and intracellular cytokines IFN-γ, TNF-α was detected. Ns. no significance, **p<0.01, ***p<0.001.