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. 2022 Jul 29;13:928593. doi: 10.3389/fimmu.2022.928593

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Copyright © 2022 Lin, Xie, Gu, Chen, Lu, Jia, Xiao, Zhang, Yu and Gong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-144/451^-/- DCs-transplantation exacerbates DSS-induced mice colitis. CD45.1⁺ WT recipient mouse was treated with 2.5% DSS, and adoptively transferred with WT (CD45.2⁺, n=6) or miR-144/451 KO (CD45.2⁺, n=6) DCs via tail vein at day -1, day 3 and day 5. Changes in body weight (A). Disease activity index of colitis (B). Morphology of colons (C), and bars represent the length of colons (D). Frequency of CD45.2⁺ cells in spleen and MLN of recipient mice (E). Expression of CD80, CD86 and IL-6 on CD45.2⁺ DCs from spleen (F, G) and MLN (H, I) of colitis mice. Ns. no significance, *p<0.05, **p<0.01, ***p<0.001.