Figure 7.

Enhanced DC activation verified by bone marrow transplantation. CD45.1⁺ WT recipient mouse was treated with busulfan and adoptively transferred with bone marrow (CD45.2⁺). Frequency of CD45.2⁺ DCs in the spleen of the recipient (A). Expression of CD80 (B), CD86 (C), I-A/I-E (D), H2K^b (E), TNF-a (F) and IL-6 (G) on CD45.2⁺ DCs. The sensibility of DSS-induced colitis was evaluated in the bone marrow transplantation model. WT (CD45.1⁺) or miR-144/451 KO bone marrow (CD45.2⁺) were injected into busulfan-treated KO or WT mice respectively (n = 5). Changes in body weight (H). Disease activity index of colitis (I). Morphology of colons, and bars represent the length of colons (J). Histological sections and pathological scores (K), 40 ×). *WT to WT vs. KO to KO, ^#WT to WT vs. KO to WT. Ns. no significance, *p<0.05, **p<0.01, ***p<0.001.