Table 2.

Mean change in serum vitamin D after treatment with selected explanatory variables

	Serum vitamin D ng/ml-Changes (after the first dose)					Effect size (Cohen's d) compared to the reference	Difference in mean compared to the reference	P value for difference in mean compared to the reference
	Range	Mean	SD	SE	N	category	category	category
Gender
Female	( − 17 to 50)	6.5	7.9	0.16	2501		Reference
Male	( − 18 to 48)	7.2	9.4	0.31	946	0.08	0.7	0.0497
Age group (years)
< 30	( − 10 to 47)	7	7.7	0.23	1119		Reference
30–39	( − 18 to 50)	6.6	8.3	0.24	1224	− 0.05	− 0.4	1[NS]
40–49	( − 18 to 48)	6.5	8.8	0.32	754	− 0.06	− 0.5	1[NS]
50–60	( − 15 to 45)	6.4	9.7	0.52	350	− 0.06	− 0.6	1[NS]
History of Diabetes Mellitus
Negative	( − 18 to 50)	6.9	8.4	0.16	2798		Reference
Positive	( − 15 to 48)	5.6	8.1	0.32	649	− 0.16	− 1.3	< 0.001
History of Hypertension
Negative	( − 18 to 50)	6.8	8.4	0.15	3021		Reference
Positive	( − 15 to 39)	5.5	7.8	0.38	426	− 0.16	− 1.3	0.001
History of Dyslipidemia
Negative	( − 18 to 50)	7	8.4	0.16	2727		Reference
Positive	( − 15 to 48)	5.5	8.2	0.3	720	− 0.18	− 1.5	< 0.001
History of Cerebrovascular Disorder
Negative	( − 18 to 50)	6.7	8.4	0.14	3394		Reference
Positive	( − 9 to 36)	4.8	7.9	1.09	53	− 0.23	− 1.9	0.09[NS]
History of Chronic Kidney Disease
Negative	( − 18 to 50)	6.7	8.3	0.14	3422		Reference
Positive	( − 8 to 31)	6.8	9.4	1.88	25	0.01	0.1	0.97[NS]
History of Asthma / Chronic Obstructive Pulmonary Disease
Negative	( − 18 to 50)	6.8	8.4	0.15	3037		Reference
Positive	( − 15 to 48)	5.6	8.1	0.4	410	− 0.14	− 1.2	0.004