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. 2022 Jul 4;2022:8566970. doi: 10.1155/2022/8566970

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Copyright © 2022 C. G. Jolivalt et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

NSI treatment restores mitochondrial complex I and cytochrome c oxidase activity in the brain cortex from ZDF rats in parallel with elevation of expression of respiratory chain proteins. Brain cortex tissues were obtained from control (Ctrl), ZDF, and NSI-treated ZDF (ZDF+NSI) rats and underwent (a–f) Western blotting or (g, h) complex I and complex IV activity assays. (b) Protein levels for (a) Cox I (NDUFB8), (b) Cox II (SDHB), (c) Cox III (UQCRC2), (d) Cox IV (MTCO1), and (e) Cox V (ATP5a). (f) Western blot image of subunits of mitochondrial complexes I-V and total ERK (T-ERK). (g) Complex I activity and (h) cytochrome c oxidase (Cox IV) activity. Data are mean ± SEM of N = 6; ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗∗p < 0.0001, analyzed by one-way ANOVA with Holm-Sidak's post hoc test.