Table 5.

Risk factors predicting the presence of liver fibrosis in all patients using APRI and Fib-4 scores over the study period (median duration of follow-up of 58.5 months). Liver fibrosis was defined using a APRI score >0.5 and for a Fib-4 score ≥1.45.

Risk factors for liver fibrosis	Univariate analysis
	OR	95% CI	P -value
Presence of liver fibrosis using APRI >0.5
Current or previous HIV-HBV co-infection	4.245	2.132–8.452	<0.001
Male gender	0.393	0.210–0.737	0.004
CD4+T cell count (cells/mm3)	0.998	0.997–0.999	<0.001
CD4+T cell count <200 cells/mm3	3.512	1.381–8.830	0.002
CD4+ T cell count <500 cells/mm3	2.484	1.425–4.328	0.002
Log10 plasma HIV RNA	1.372	1.030–1.829	0.018
Detectable HIV RNA	1.760	1.047–2.958	0.022
Serum cholesterol (mg/dl)	0.984	0.973–0.994	0.002
Serum triglycerides (mg/dl)	0.994	0.989–0.998	0.003
Presence of liver fibrosis using Fib-4 ≥1.45
Male gender	2.760	1.202–6.336	0.017
CD4+ T cell count	0.998	0.997–0.999	<0.001
CD4+ T cell count <200 cells/mm3	2.414	1.014–5.747	0.016
CD4+ T cell count <500 cells/mm3	2.836	1.501–5.355	0.001
Log10 plasma HIV RNA	1.407	1.031–1.919	0.005
Serum cholesterol (mg/dl)	0.988	0.978–0.998	0.003
Non-adherence to ART	2.641	1.070–6.515	0.035