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. 2022 Aug 5;55:102427. doi: 10.1016/j.redox.2022.102427

Fig. 3.

Fig. 3

Knockdown Nav1.8 attenuated psoriasis-like development in mice. A, Schematic diagram of NC/Nav1.8 siRNA-injected mice treated with IMQ or control. B, The mRNA levels of Nav1.8 silenced by siRNA in the skin tissues from IMQ-induced inflammation mice. Data represents the mean ± SEM. and *p < 0.05, **p < 0.01.2-way ANOVA test was used. C, The ears of NC and Nav1.8 knockdown mice treated with IMQ or control. D, The erythema score, scales score and ear thickness of psoriasis-induced inflammation mice. For statistical analysis, siRNA-IMQ group was compared with NC-IMQ group, *p < 0.05, **p < 0.01, ***p < 0.001.1-way ANOVA test was used. E, HE staining of lesional skin of WT and Nav1.8 knockdown mice treated with IMQ. F, The Ki67 expression visualized by immunofluorescence. G, The mRNA levels of IL1β, IL-6, IL17-A, IL-17F, IL-22, IL23A in IMQ-induced inflammation mice. H, The flow cytometry analysis revealed the immune cells infiltration in the skin lesion of IMQ-induced inflammation mice.