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. 2022 Aug 5;55:102427. doi: 10.1016/j.redox.2022.102427

Fig. 4.

Fig. 4

Nav1.8 promoted the progression inflammatory skin disease by regulating cytokines expression in keratinocytes. A, The upregulated genes in NC_LL37 group compared to NC_PBS group. B, The downregulated genes in NC_LL37 group compared to NC_PBS group. C, The GO and KEGG enrichment analysis of the 2390 genes upregulated in NC_LL37 group which were attenuated by Nav1.8 siRNA. D, The T cell activation, Th1/Th17 differentiation, macrophage and neutrophils activation-related genes expression in NC_LL37 group compared to NC_PBS group and in Si_LL37 group compared to NC_LL37 group. E, PPI network analysis revealed the hub genes of these immune-cell related genes. F, The IL1β and IL6 expression in the keratinocytes of rosacea and psoriasis from HRA000809 and GSE166388 datasets. Data represents the mean ± SEM. *p < 0.05, **p < 0.01. Two-tailed unpaired Student's t-test was used. G, The IL1β and IL6 expression in skin lesion from NC and Nav1.8 knockdown mice injected with LL37 or PBS. H, The IL1β and IL6 expression in skin lesion from NC and Nav1.8 knockdown mice treated with IMQ or control visualized by immunofluorescence.