Table 3. Effectiveness outcomes.
| Outcome | S group | L group | RR or median difference (95% CI) | P value |
|---|---|---|---|---|
| Primary outcome | ||||
| CPSP at 3 mo | 13 (33.3) | 5 (12.8) | 0.600 (0.399–0.902) | 0.032 |
| Secondary outcomes | ||||
| CPSP at 1 mo | 7 (17.5) | 3 (7.3) | 2.687 (0.643–11.235) | 0.194 |
| CPSP at 6 mo | 11 (29.7) | 4 (10.5) | 0.591 (0.388–0.900) | 0.038 |
| SF-MPQ scores (0–45) | ||||
| At 1 mo | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.195 |
| At 3 mo | 33.0 (0.0–35.0) | 0.0 (0.0–29.0) | 0.0 (0.0–0.0) | 0.022 |
| At 6 mo | 29.0 (0.0–34.0) | 0.0 (0.0–28.3) | 0.0 (0.0–0.0) | 0.037 |
| SF-MPQ-S scores (0–33) | ||||
| At 1 mo | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.189 |
| At 3 mo | 24.0 (0.0–27.0) | 0.0 (0.0–21.0) | 0.0 (0.0–0.0) | 0.019 |
| At 6 mo | 20.0 (0.0–24.0) | 0.0 (0.0–21.2) | 0.0 (0.0–0.0) | 0.039 |
| SF-MPQ-A scores (0–12) | ||||
| At 1 mo | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.155 |
| At 3 mo | 9.0 (0.0–11.0) | 0.0 (0.0–8.0) | 0.0 (0.0–0.0) | 0.024 |
| At 6 mo | 9.0 (0.0–9.2) | 0.0 (0.0–7.0) | 0.0 (0.0–0.0) | 0.021 |
| Neuropathic pain* | ||||
| At 1 mo | 4 (10.3) | 2 (4.9) | 2.229 (0.384–12.923) | 0.426 |
| At 3 mo | 6 (15.8) | 4 (10.3) | 1.641 (0.424–6.347) | 0.470 |
| At 6 mo | 4 (11.1) | 3 (7.9) | 1.458 (0.303–7.023) | 0.707 |
| Pain severity† | ||||
| At 1 mo | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.397 |
| At 3 mo | 0.0 (0.0–2.0) | 0.0 (0.0–0.5) | 0.0 (0.0–0.0) | 0.452 |
| At 6 mo | 0.0 (0.0–0.3) | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.622 |
| Pain interference‡ | ||||
| At 1 mo | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.347 |
| At 3 mo | 0.0 (0.0–2.2) | 0.0 (0.0–0.4) | 0.0 (0.0–0.0) | 0.358 |
| At 6 mo | 0.0 (0.0–0.4) | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | 0.510 |
Data are number (%), median (interquartile range), or mean ± SD. *, defined as a score of ≥4 on the DN-4 scale; †, scores of pain severity on the Brief Pain Inventory-Short Form; ‡, scores of pain interference on the Brief Pain Inventory-Short Form. S, control; L, lidocaine; RR, relative risk; CPSP, chronic postoperative pain; SF-MPQ, short-form McGill pain questionnaire; SF-MPQ-S, short-form McGill pain questionnaire-sensitive; SF-MPQ-A, short-form McGill pain questionnaire-affective; DN-4, Neuropathic Pain Score.