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. 2022 Jul 29;13:869365. doi: 10.3389/fimmu.2022.869365

Figure 4.

Figure 4

Macrophages depletion prevents protective effects of exogenous IL-33 on hepatic IRI (A) Representative FACS analysis showing depletion of macrophages following administration of Clodronate Liposomes (CL). (B) Serum ALT and AST levels of mice in PBS+control, PBS+CL, IL33+control and IL33+CL groups 12 h after IRI. (C) Histopathological changes in livers within the different treatment groups 12 h after IRI. (D) Suzuki’s Scores quantifying the capacity for CL to attenuate the protective effects of exogenous IL-33 against hepatic IRI (n=6 per group) (mice were Euthanized 12h after IRI). (E) Histochemistry of caspase3 and PCNA in the four groups (mice were euthanized 12h after IRI). (*P<0.05, **P<0.01).