Table 5c.
Average cytokine concentration at day0 (pre-vaccination) and day56 or day42 (post second-dose).
| Formulation | Average Interferon-gamma concentration (pg/mL) |
Average IL-4 concentration (pg/mL) |
||||||
|---|---|---|---|---|---|---|---|---|
| D-0 Null | D-0 Active | D-56 Null | D-56 Active | D-0 Null | D-0 Active | D-56 Null | D-56 Active | |
| C | 1·99 | 5·59 | 2·08 | 22·03 | 1·06 | 1·69 | 1·02 | 1·60 |
| B | 2·04 | 3·73 | 1·91 | 31·42 | 3·77 | 3·72 | 2·73 | 3·19 |
| E | 7·03 | 26·24 | 2·63 | 99·82 | 5·19 | 4·26 | 8·10 | 10·96 |
D-0: Day0; D-56: Day56; IL-4: Interleukin 4; pg/mL: picograms per milliliter.
Note: The cytokine concentrations are measured in the supernatants of whole-blood samples incubated in tubes coated with SARS-COV-2 peptides (Active) and without coating (Null) for a subset of subjects from Formulation C&B cohorts from Phase-1/2 study and Formulation-E cohort from Phase-2 study.