Table 3.

Genomic mechanisms of antimicrobial resistance identified in Isolates 3, 4, and 5.

Antibacterial	Resistance determinants	Location in Isolate 3	Isolate 3	Isolate 4	Isolate 5
Ampicillin	pbp5 (Val24Ala, Ser27Gly, Arg34Gln, Gly66Glu, Ala68Thr, Glu85Asp, Glu100Gln, Lys144Gln, Thr172Ala, Leu177Ile, Asp204Gly, Ala216Ser, Thr324Ala, Met485Ala, Asn496Lys, Ala499Thr, Glu525Asp, Glu629Val, Pro667S)	Chromosome	+	+	+
Linezolid	23S rRNA gene G2576T	Chromosome	~ 3/6 copies	~ 3/6 copies	~ 2/6 copies
Daptomycin	liaS (Thr120Ala)	Chromosome	+	+	+
	liaR (Trp73Cys)	Chromosome	+	+	+
	cls (Asp13Ile)	Chromosome	+	+	+
Vancomycin	vanHAX	Plasmid 3	+	+	+
	vanSR	Plasmid 3	+	+	+
	vanZY	Plasmid 3	+	+	+
Fluoroquinolones	gyrA (Ser83Tyr)	Chromosome	+	+	+
	parC (Ser80Arg)	Chromosome	+	+	+
Aminoglycosides	aac(6′)-I	Chromosome	+	+	+
	aph(3′)-IIIa	Plasmid 3	+	–	+
	ant(6)-Ia	Plasmid 3	+	–	+
Trimethoprim	dfrF	Chromosome	+	+	+
	dfrG	Chromosome	+	+	+
Tetracyclines	tetL	Chromosome	+	+	+
	tetM	Chromosome	partial and complete copy	partial copy	partial copy
Streptothricin	sat4	Plasmid 3	+	–	+
Macrolides	msrC	Chromosome	+	+	+
	ermB	Plasmid 3	+	–	+