Table 2.
The difference of echocardiography parameter between FUNDC1f/f mice or FUNDC1CKO mice treated with empagliflzoin (EMPA) after acute kidney injury-induced CRS-3.
| Parameter | FUNDC1f/f mice |
FUNDC1CKO mice |
||||
|---|---|---|---|---|---|---|
| Sham | CRS-3 | CRS-3+ EMPA | Sham | CRS-3 | CRS-3+ EMPA | |
| IVSd (mm) | 1.08 ± 0.07 | 1.09 ± 0.06 | 1.10 ± 0.08 | 1.09 ± 0.08 | 1.10 ± 0.09 | 1.09 ± 0.07 |
| IVSs (mm) | 1.27 ± 0.06 | 1.25 ± 0.09 | 1.27 ± 0.08 | 1.29 ± 0.08 | 1.26 ± 0.07 | 1.28 ± 0.07 |
| LVIDd (mm) | 3.30 ± 0.26 | 3.31 ± 0.17 | 3.29 ± 0.22 | 3.27 ± 0.26 | 3.30 ± 0.19 | 3.27 ± 0.26 |
| LVIDs (mm) | 2.31 ± 0.18 | 2.30 ± 0.17 | 2.29 ± 0.18 | 2.26 ± 0.19 | 2.27 ± 0.21 | 2.28 ± 0.18 |
| LVPWd (mm) | 0.89 ± 0.08 | 0.91 ± 0.07 | 0.89 ± 0.09 | 0.91 ± 0.09 | 0.88 ± 0.06 | 0.89 ± 0.10 |
| LVPWs (mm) | 1.15 ± 0.07 | 1.14 ± 0.09 | 1.14 ± 0.06 | 1.12 ± 009 | 1.15 ± 0.07 | 1.13 ± 0.08 |
| LVESV(μL) | 22.13 ± 2.85 | 23.04 ± 2.76 | 22.96 ± 2.12 | 22.77 ± 2.40 | 22.84 ± 2.31 | 23.12 ± 2.42 |
| LVEDV (μL) | 49.75 ± 5.05 | 49.35 ± 4.94 | 50.12 ± 4.87 | 51.11 ± 4.90 | 50.24 ± 5.11 | 50.18 ± 5.32 |
| LVEF (%) | 64 ± 6 | 42 ± 2# | 59 ± 6∗ | 65 ± 5 | 44 ± 3## | 42 ± 3∗∗ |
| LVFS(%) | 33 ± 2 | 20 ± 3# | 30 ± 3∗ | 34 ± 3 | 21 ± 2## | 22 ± 3∗∗ |
| LVM(mg) | 124.68 ± 10.35 | 155.47 ± 11.79# | 135.24 ± 13.15∗ | 125.78 ± 12.67 | 158.63 ± 12.11## | 157.97 ± 10.38∗∗ |
| E/A | 1.33 ± 0.05 | 0.75 ± 0.05# | 1.38 ± 0.06∗ | 1.35 ± 0.06 | 0.77 ± 0.04## | 0.78 ± 0.05∗∗ |
LVIDs: left ventricular internal dimension at end systole, LVIDd: left ventricular internal diameter at end diastole, LVESV: left ventricular end systolic volume, LVEDV:left ventricular end diastolic volume, LVPWs: left ventricular posterior wall depth at end systole, LVPWd: left ventricular posterior wall depth at end diastole, IVSs: interventricular septum depth at end systole, IVSd: interventricular septum depth at end diastole, LVEF: left ventricular ejection fraction, LVFS: left ventricular fractional shortening, LVM: left ventricular mass. #p < 0.05 vs. FUNDC1f/f mice in sham group, ∗p < 0.05 vs. FUNDC1f/f mice in CRS-3 group, ##p < 0.05 vs. FUNDC1CKO mice in sham group, ∗∗p < 0.05 vs. FUNDC1f/f mice in CRS-3+EMPA group.